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BCL11A Polyclonal antibody

BCL11A Polyclonal Antibody for IHC, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

IHC, ELISA

Conjugate

Unconjugated

Cat no : 11613-1-AP

Synonyms

B cell CLL/lymphoma 11A, B cell lymphoma/leukemia 11A, BCL11A, COUP TF interacting protein 1, CTIP1, EVI 9, EVI9, HBFQTL5, KIAA1809, ZNF856

Validation Data Gallery

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  • Immunohistochemistry (IHC) staining of human tonsillitis tissue using BCL11A Polyclonal antibody (11613-1-AP)

    IHC staining of human tonsillitis using 11613-1-AP

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 11613-1-AP (BCL11A antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • Immunohistochemistry (IHC) staining of human tonsillitis tissue using BCL11A Polyclonal antibody (11613-1-AP)

    IHC staining of human tonsillitis using 11613-1-AP

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 11613-1-AP (BCL11A antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • Immunohistochemistry (IHC) staining of human gliomas tissue using BCL11A Polyclonal antibody (11613-1-AP)

    IHC staining of human gliomas using 11613-1-AP

    Immunohistochemical analysis of paraffin-embedded human gliomas tissue slide using 11613-1-AP (BCL11A antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • Immunohistochemistry (IHC) staining of human gliomas tissue using BCL11A Polyclonal antibody (11613-1-AP)

    IHC staining of human gliomas using 11613-1-AP

    Immunohistochemical analysis of paraffin-embedded human gliomas tissue slide using 11613-1-AP (BCL11A antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

Tested Applications

Positive IHC detected inhuman tonsillitis tissue, human gliomas tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

11613-1-AP targets BCL11A in IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen BCL11A fusion protein Ag2187
Full Name B-cell CLL/lymphoma 11A (zinc finger protein)
Calculated Molecular Weight 835 aa, 91 kDa
GenBank Accession NumberBC021098
Gene Symbol BCL11A
Gene ID (NCBI) 53335
RRIDAB_2259028
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Background Information

B-CELL CLL/LYMPHOMA 11A(BCL11A)is a highly conserved zinc finger gene. It acts as a myeloid and B-cell proto-oncogene, and may play key roles in leukemogenesis and hematopoiesis. It is an essential factor in lymphopoiesis, and required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1. It is also involved in lymphoid malignancies through translocation or amplification events. It has recently been shown that BCL11A expression is inversely correlated with γ globin expression.(PMID:21156846). This is a rabbit polyclonal antibody raised against part chain of N-terminal BCL11A of human origin. There are three isoforms of BCL11A: isoform1(773aa), isoform2(486aa) and isoform3(239aa)

Protocols

Product Specific Protocols
IHC protocol for BCL11A antibody 11613-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols