BCR Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 22585-1-AP

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Freight/Packing

Con: 68 μg/150 μl

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Species specificity:
human, monkey

Positive WB detected in:
Y79 cells, COS-7 cells, HEK-293 cells, HeLa cells, K-562 cells, MCF-7 cells

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human skin tissue

Positive IF detected in:
HeLa cells, HepG2 cells

Positive FC detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen Affinity purified

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
breakpoint cluster region

Calculated molecular weight:
143 kDa

Observed molecular weight:
150-160 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BCR

Synonyms
ALL, BCR, breakpoint cluster region, CML, D22S11, D22S662, PHL
Background

The Bcr gene, mapping on chromosome22, was orginally identified by its presence in the chimeric Bcr-Abl oncogene. The Bcr gene encodes for the break point cluster region protein(Bcr). Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for RAC1 and CDC42. A chromosomal aberration involving BCR has been found in patients with chronic myeloid leukemia.


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