BCR Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 22585-1-AP

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Freight/Packing

Con: 68 μg/150 μl

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Species specificity:
human, monkey

Positive WB detected in:
Y79 cells, COS-7 cells, HEK-293 cells, HeLa cells, K-562 cells, MCF-7 cells

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human skin tissue

Positive IF detected in:
HeLa cells, HepG2 cells

Positive FC detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen Affinity purified

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
breakpoint cluster region

Calculated molecular weight:
143 kDa

Observed molecular weight:
150-160 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BCR

Synonyms
ALL, BCR, breakpoint cluster region, CML, D22S11, D22S662, FLJ16453, PHL
Background

The Bcr gene, mapping on chromosome22, was orginally identified by its presence in the chimeric Bcr-Abl oncogene. The Bcr gene encodes for the break point cluster region protein(Bcr). Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for RAC1 and CDC42. A chromosomal aberration involving BCR has been found in patients with chronic myeloid leukemia.


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