BIN1 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 14647-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 66 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
Jurkat cells, mouse brain tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human osteosarcoma tissue

Recommended dilution:
WB : 1:500-1:2400
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
bridging integrator 1

Calculated molecular weight:
65 kDa

Observed molecular weight:
60-65 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
BIN1

Synonyms
AMPH2, Amphiphysin II, Amphiphysin like protein, AMPHL, BIN1, bridging integrator 1, DKFZp547F068, SH3P9
Background

BIN1 (Bridging integrator 1), also known as amphiphysin II or Myc box-dependent-interacting protein 1, is a ubiquitous nucleocytoplasmic adaptor protein that was identified initially as an MYC-interacting proapoptotic tumor suppressor. Alternate splicing of the gene results in multiple transcript variants encoding different isoforms. BIN1 is a key regulator of different cellular functions, including endocytosis and membrane recycling, cytoskeleton regulation, DNA repair, cell cycle progression, and apoptosis (PMID: 24590001).


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