C9orf86 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 20848-1-AP

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Freight/Packing

Con: 49 μg/150 μl

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Species specificity:
human

Positive WB detected in:
MDA-MB-453s cells

Positive IHC detected in:
human breast cancer tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
chromosome 9 open reading frame 86

Calculated molecular weight:
729aa,80 kDa

Observed molecular weight:
125 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
C9orf86

Synonyms
bA216L13.9, C9orf86, FLJ10101, FLJ13045, Parf, Partner of ARF, pp8875, RBEL1
Background

C9orf86, also known as RBEL1 (Rab-like protein 1), is a novel subfamily of GTPases within the Ras superfamily. It has two splice variants, RBEL1Aand RBEL1B. Unlike known Rabs that aremostly cytosolic, RBEL1B predominantly resides in the nucleus, whereas RBEL1A is localized primarily to the cytosol. C9orf86 is overexpressed in the majority of primary breast tumors, and knockdown of C9orf86 in MCF-7 breast cancer cells resulted in cell growth suppression associated with apoptosis [PMID: 23977139]. Western blot analysis revealed that the endogenous RBEL1 migrated at 110-125 kDa, 80 kDa, maybe due to a number of potential O-linked glycosylation sites.[PMID: 17962191]


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