CA8 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 12391-1-AP

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Freight/Packing

Con: 50 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse skeletal muscle tissue, mouse brain tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human gliomas tissue

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
carbonic anhydrase VIII

Calculated molecular weight:
290aa,32 kDa

Observed molecular weight:
32 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CA8

Synonyms
CA VIII, CA8, CALS, carbonic anhydrase VIII, CARP
Background

The CA8 (CARP) gene encodes carbonic anhydrase VIII, which is part of a family of zinc metalloenzyme. CA8 has a central carbonic anhydrase motif, but it lacks carbonic anhydrase activity due to absence of catalytic zinc coordinating residues(PMID:2121526). CARP is a novel IP3R1-binding protein, and is expressed in Purkinje cells abundantly. CA8 is co-localized with IP3R1 in Purkinje cells and it binds to IP3R1, reducing the affinity of the receptor for its ligand, IP3(PMID:12611586). Defects in CA8 are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 3 (CMARQ3)(PMID:19461874).


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