CAPZA1 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 55145-1-AP

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Freight/Packing

Con: 20 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
human heart tissue, mouse brain tissue, mouse heart tissue

Positive IHC detected in:
human colon cancer tissue, human colon cancer tissue, human stomach cancer tissue

Recommended dilution:
WB : 1:200-1:1000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
capping protein (actin filament) muscle Z-line, alpha 1

Calculated molecular weight:
33 kDa

Observed molecular weight:
34-40 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CAPZA1

Synonyms
CAPPA1, CAPZ, CapZ alpha 1, CAPZA1, CAZ1
Background

CAPZA1 belongs to the F-actin-capping protein alpha subunit family. F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. The potential for CAPZ is a therapeutic target in the management of heart failure. Future research is required to determine the mechanisms by which changes in CAPZ impact myocardial function and intracellular signalling, and to develop feasible strategies that can manipulate CAPZ in the intact heart. (PMID: 15614336 ) This antibody is specific to CAPZA1.


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