MLN51/CASC3 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 18047-1-AP

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Freight/Packing

Con: 50 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
A2780 cells, Jurkat cells, MCF-7 cells, SKOV-3 cells

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2400
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cancer susceptibility candidate 3

Calculated molecular weight:
703aa,76 kDa

Observed molecular weight:
115-120 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CASC3

Synonyms
BTZ, CASC3, MLN 51, MLN51, Protein barentsz, Protein CASC3
Background

CASC3(cancer susceptibility candidate 3) is also named as MLN51 and belongs to the CASC3 family. It is induced by CSF2, and is important in the proliferation of RA fibroblast-like synoviocytes in the pathogenesis of rheumatoid arthritis (RA)(PMID:17101062). It is a nucleocytoplasmic protein containing, within its aminoterminal half, a coiled-coil domain followed by two nuclear localization signals (NLSs) responsible for nuclear localization and, in its carboxyl-terminal half, a nuclear export signal(NES) that mediates cytoplasmic retention. It possesses many potential phosphorylation sites and is found to be phosphorylated in both normal and cancer-derived cells.(PMID:17652158).


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