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- KD/KO Validated
Calcium Sensing Receptor Polyclonal antibody
Calcium Sensing Receptor Polyclonal Antibody for IF, WB,ELISA
Cat no : 19125-1-AP
|Positive WB detected in||COLO 320 cells, HL-60 cells, Jurkat cells|
|Positive IF detected in||Hela cells|
|Western Blot (WB)||WB : 1:500-1:2000|
|Immunofluorescence (IF)||IF : 1:10-1:100|
|Sample-dependent, check data in validation data gallery|
19125-1-AP targets Calcium Sensing Receptor in WB, IHC, IF,ELISA applications and shows reactivity with human, mouse, rat samples.
|Tested Reactivity||human, mouse, rat|
|Cited Reactivity||human, mouse, rat|
|Host / Isotype||Rabbit / IgG|
|Full Name||calcium-sensing receptor|
|Calculated molecular weight||121 kDa|
|Observed molecular weight||140 kDa, 60-65 kDa|
|GenBank accession number||NM_000388|
|Gene ID (NCBI)||846|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
CASR, also named as GPRC2A, PCAR1, belongs to the G-protein coupled receptor 3 family. Changes in extracellular calcium are thought to modulate a balance between proliferation and differentiation in a variety of cell types. The activity of CASR is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. It has been shown to play a major role in regulating parathyroid hormone secretion and subsequently influencing the calcium concentration of extracellular fluids. In normal primary keratinocytes and breast epithelial cells, proliferation is inhibited and elevated extracellular calcium levels trigger differentiation. Malignant transformations of these cell types are accompanied by a loss of responsiveness to the anti-proliferative effects of elevated extracellular calcium. Several disorders of calcium homeostasis have been linked to mutations in the CaSR. These include familial hypocalciuric hypercalcemia (FHH), neonatal severe hyperparathyroidism (NSHPT), and autosomal dominant hypocalemia (ADHypo). The 60-65 kDa band detected by this antibody might represent a degradation product of CASR (PMID: 15718278).
Biol Pharm Bull
Calhex231 alleviates high glucose-induced myocardial fibrosis via inhibiting Itch-ubiquitin proteasome pathway in Vitro.
Am J Physiol Cell Physiol
miR-429 and miR-424-5p inhibit cell proliferation and Ca2+ influx by downregulating CaSR in pulmonary artery smooth muscle cells.
Hum Exp Toxicol
Role of autophagy in cadmium-induced testicular injury.
Ann Transl Med
Renal tubular injury induced by glyphosate combined with hard water: the role of cytosolic phospholipase A2.
Acta Pharmacol Sin
Astragaloside IV attenuates myocardial ischemia/reperfusion injury in rats via inhibition of calcium-sensing receptor-mediated apoptotic signaling pathways.
Calcium Sensing Receptor-Related Pathway Contributes to Cardiac Injury and the Mechanism of Astragaloside IV on Cardioprotection.