CBX4 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 18544-1-AP

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Con: 40 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
Various cell, HEK-293 cell, PC-3 cells

Positive IF detected in:
U2OS cell, HeLa cells

Recommended dilution:
WB : N/A
IF : N/A

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
chromobox homolog 4 (Pc class homolog, Drosophila)

Calculated molecular weight:
61 kDa

Observed molecular weight:
~75 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CBX4

Synonyms
CBX4, Chromobox protein homolog 4, E3 SUMO protein ligase CBX4, hPC2, NBP16, PC2, Polycomb 2 homolog
Background

CBX4, also named as E3 SUMO-protein ligase CBX4 or Polycomb 2 homolog, is a 560 amino acid protein, which contains 1 chromo domain. CBX4 facilitates SUMO1 conjugation by UBE2I. CBX4 acting as a transcriptional co-repressor is involved in maintaining the transcriptionally repressive state of genes, modifies chromatin, rendering it heritably changed in its expressibility. CBX4 localizes in the nucleus and is widely expressed in various tissues. The calculated molecular weight of CBX4 is 61 kDa, but the modified CBX4 may be a 70-75 kDa protein.


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