Cyclin A1 Polyclonal antibody

Cyclin A1 Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB,ELISA

Conjugate

Unconjugated

Cat no : 13295-1-AP

Synonyms

CCNA1, cyclin A1



Tested Applications

Recommended dilution

ApplicationDilution
Sample-dependent, check data in validation data gallery

Published Applications

WBSee 16 publications below

Product Information

13295-1-AP targets Cyclin A1 in WB,ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivity human, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Cyclin A1 fusion protein Ag4005
Full Name cyclin A1
Calculated molecular weight 464 aa, 52 kDa
GenBank accession numberBC036346
Gene symbol CCNA1
Gene ID (NCBI) 8900
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

CCNA1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. CCNA1 binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. CCNA1 was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. In general, the expression of CCNA1 is tissue-specific and high CCNA1 expression is limited to testis; besides, lower levels of CCNA1 expression are also observed in other human cell lines and in healthy brain. Currently, CCNA1 expression has been illustrated to be downregulated in various tumors, including head and neck squamous-cell cancer (HNSCC) and nasopharyngeal carcinoma; and the promoter of the CCNA1 gene is found to be frequently methylated in colon cancer and HNSCC.

Publications

SpeciesApplicationTitle
humanWB

Biochim Biophys Acta

BMP-6 inhibits cell proliferation by targeting microRNA-192 in breast cancer.

Authors - Hu Fen F
humanWB

Tumour Biol

The role of RhoA in vulvar squamous cell carcinoma: a carcinogenesis, progression, and target therapy marker.

Authors - Jing Wang
humanWB

Biomed Res Int

LncRNA CAR10 Upregulates PDPK1 to Promote Cervical Cancer Development by Sponging miR-125b-5p.

Authors - Tingting Hu
mouseWB

Exp Ther Med

Cyclin-dependent kinase 1 disruption inhibits angiogenesis by inducing cell cycle arrest and apoptosis.

Authors - Xin Gao
humanWB

Biosci Biotechnol Biochem

BAF45D knockdown decreases cell viability, inhibits colony formation, induces cell apoptosis and S-phase arrest in human pancreatic cancer cells.

Authors - Zengyi Liu
humanWB

Histol Histopathol

LncRNA AY343892 inhibits breast cancer development by positively regulating BRCA1-mediated transcription of PTEN.

Authors - Yan Li