TEM1 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 18160-1-AP

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Freight/Packing

Con: 35 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, A375 cells, COLO 320 cells, HEK-293 cells, HeLa cells, mouse colon tissue, mouse heart tissue, mouse stomach tissue, NIH/3T3 cells, SH-SY5Y cells

Positive IHC detected in:
human lung cancer tissue, human gliomas tissue, human lung cancer tissue, human renal cell carcinoma tissue

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
CD248 molecule, endosialin

Calculated molecular weight:
757aa,81 kDa

Observed molecular weight:
81 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CD248

Synonyms
CD164L1, CD248, CD248 molecule, endosialin, Endosialin, TEM1, Tumor endothelial marker 1
Background

TEM1 (Tumor endothelial marker 1), also named as CD248, Endosialin and CD164L1, is a C-type lectin-like domain (CTLD) containing type I transmembrane glycoprotein. It is now considered to be a highly selective marker for activated perivascular and stromal cells, detected in most cancers and at least some inflammatory disorders. CD248 plays a role in tumor angiogenesis. It is a potential diagnostic tool and therapeutic target of inflammatory and malignant disease. Two isoforms of human TEM1 exist. The calculated molecular weights of the two isoforms are 81 kDa and 46 kDa, respectively. Native TEM1 can be glycosylated, and the glycosylated form has a larger apparent molecular weight than 81 kDa.


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