- Featured Product
- KD/KO Validated
CD38 Monoclonal Antibody for IF, WB, ELISA
Cat no : 60006-1-Ig
ADP ribosyl cyclase 1, cADPr hydrolase 1, CD38, CD38 molecule, Cyclic ADP ribose hydrolase 1, T10
|Positive WB detected in||Jurkat cells, Raji cells|
|Positive IF detected in||NIH/3T3 cells|
|Western Blot (WB)||WB : 1:500-1:2000|
|Immunofluorescence (IF)||IF : 1:10-1:100|
|Sample-dependent, check data in validation data gallery|
60006-1-Ig targets CD38 in IF, WB, ELISA applications and shows reactivity with human, mouse samples.
|Cited Species||human, mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||CD38 fusion protein Ag0487|
|Full Name||CD38 molecule|
|Calculated molecular weight||300aa,34 kDa|
|Observed molecular weight||45 kDa|
|GenBank accession number||BC007964|
|Gene ID (NCBI)||952|
|Purification Method||Protein G purification|
|Storage Buffer||PBS with 0.1% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20oC. Aliquoting is unnecessary for -20oC storage.|
CD38, also known as ADP-ribosyl cyclase 1, is a type II transmembrane glycoprotein with a short N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites (PMID: 2319135). The extracellular domain of CD38 has bifunctional enzyme activities that catalyze synthesis of cyclic ADP ribose from nicotinamide adenine dinucleotide (NAD) and hydrolysis of cyclic ADP ribose to adenosine diphosphoribose (PMID: 10636863). CD38 is expressed on a variety of hematopoietic and non-hematopoietic cells and is involved in diverse processes such as generation of calcium-mobilizing metabolites, cell activation, and chemotaxis (PMID: 25938500).
Activation of astrocytic sigma-1 receptor exerts antidepressant-like effect via facilitating CD38-driven mitochondria transfer.
PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance.