CD47 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 20305-1-AP

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Freight/Packing

Con: 37 μg/150 μl

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Species specificity:
human

Positive WB detected in:
Jurkat cells

Positive IHC detected in:
human ovary tumor tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
CD47 molecule

Calculated molecular weight:
323aa,35 kDa

Observed molecular weight:
47-55 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CD47

Synonyms
CD47, CD47 molecule, IAP, Leukocyte surface antigen CD47, MER6, OA3, Protein MER6
Background

CD47, also known as integrin-associated protein (IAP), is a member of the immunoglobulin superfamily containing a five-pass transmembrane attachment. CD47 is heavily glycosylated and widely expressed by hematopoietic and nonhematopoietic cells. CD47 interacts with several membrane integrins and also acts a receptor for thrombospondin (THBS1). It is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. CD47 also functions as a ligand for signal regulatory protein-α (SIRPα). Upon binding CD47, SIRPα initiates a signaling cascade that results in the inhibition of phagocytosis.


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