Cadherin-13 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 12618-1-AP

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Con: 33 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
mouse heart tissue, human heart tissue, L02 cells

Positive IP detected in:
mouse heart tissue

Positive IHC detected in:
human endometrial cancer tissue, human heart tissue

Positive FC detected in:
Jurkat cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cadherin 13, H-cadherin (heart)

Calculated molecular weight:
713aa,78 kDa

Observed molecular weight:
105 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CDH13

Synonyms
Cadherin 13, Cadherin-13, CDH13, CDHH, H cadherin, H-cadherin, Heart cadherin, P105, T cad, T cadherin, T-cadherin, Truncated cadherin
Background

Cadherins are a family of transmembrane glycoproteins that mediate calcium-dependent cell-cell adhesion and play an important role in the maintenance of normal tissue architecture. Cadherin-13 (CDH13, also known as H-cadherin or T-cadherin) is an atypical member of cadherin family, lacking transmembrane and cytosolic domains and anchored to the exterior surface of the plasma membrane via a GPI anchor. CDH13 is thought to affect cellular behavior largely through its signaling properties. It is highly expressed in heart, and in the CNS, CDH13 is expressed in cerebral cortex, medulla, hippocampus, amygdala, thalamus and substantia nigra. It is often down-regulated in cancerous cells. The CDH13 cDNA encodes a 713-amino acid protein, which has a calculated molecular weight of 78 kDa. Studies have detected variable bands on Western blots, including 105 kDa (mature form), 130 kDa (precursor), and 45 kDa, which may be a post-translational processing variant of CDH13 (PMID: 19399994).


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