CDR2 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 11611-2-AP

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Con: 60 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human brain tissue, Y79 cells

Positive IHC detected in:
human breast cancer tissue

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cerebellar degeneration-related protein 2, 62kDa

Calculated molecular weight:
454aa,52 kDa

Observed molecular weight:
62 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CDR2

Synonyms
CDR2, CDR62, PCD17, Yo
Background

Patients with paraneoplastic cerebellar degeneration (PCD) carry a characteristic antibody called anti-Yo. On Western blot analysis of Purkinje cells and tumor tissue from CD patient, the anti-Yo sera react with at least 2 antigens, a major species of 62 kD called CDR62 or CDR2 [PMID:18045792]. CDR2 is partly characterized, as CDR2 through its leucine zipper motif has been demonstrated to interact with c-myc, with cell cycle-related proteins and with a protein kinase, indicating that CDR2 is involved in signal transduction and gene transcription. Furthermore, CDR2 has been found to attenuate hypoxic response in renal cell carcinoma, and recent data suggest a role for CDR2 and c-myc in mitosis in cycling cells [PMID:21080165].


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