CENPA Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 26754-1-AP

  • Print page
  • Download PDF

-_-

Freight/Packing

Con: 55 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human

Positive WB detected in:
MCF-7 cells, Jurkat cells

Recommended dilution:
WB : 1:500-1:1000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
centromere protein A

Calculated molecular weight:
16 kDa

Observed molecular weight:
16 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CENPA

Synonyms
CENP A, CENPA, Centromere autoantigen A, centromere protein A
Background

Centromere protein-A (CENP-A) is a Histone H3-like protein that contains a C-terminal H3-like domain, required for centro-mere localization of CENP-A, and an antigenic N-terminal domain. CENP-A, originally isolated from HeLa cells, is essential for kinetochore targeting of CENP-C. In the presence of DNA, CENP-A forms an octameric complex with histones H4, H2A and H2B. CENP-A specifically localizes to active centromeres and is a component of specialized centromeric nucleosomes, on which kinetochores are assembled. CENP-A is essential for nucleosomal packaging of centromeric DNA at interphase and functions as a centromere formation marker on the chromosome.


Back
to top