CHMP1A Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 15761-1-AP

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Freight/Packing

Con: 40 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
HEK-293 cells, A431 cells, HeLa cells, mouse kidney tissue, mouse lung tissue

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human testis tissue, human brain tissue, human lung tissue, human placenta tissue, human skin tissue, human testis tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
chromatin modifying protein 1A

Calculated molecular weight:
196aa,22 kDa

Observed molecular weight:
33 kDa ,25 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CHMP1A

Synonyms
CHMP1, CHMP1A, chromatin modifying protein 1A, hVps46 1, KIAA0047, PCOLN3, PRSM1, Vps46 1
Background

Charged multivesicular body protein 1A (CHMP1A), also known as chromatin modifying protein 1A, is a member of the ESCRT-III (endosomal sorting complex required for transport III) complex which is involved in degradation of internalized transmembrane receptor proteins and formation of multivesicular bodies (MVBs) (PMID: 16730941). CHMP1A has both nuclear and cytoplasmic distributions (PMID: 11559748; 11559747). Subcellular localization of CHMP1A seems to vary depending on the cell type (PMID: 23023333). CHMP1A is required for MVBs formation and has a role in stable gene silencing within the nucleus. Besides, the tumor suppressor role of CHMP1A has also been reported (PMID: 18787405; 22261332).


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