CHMP4B Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 13683-1-AP

Featured Product KD/KO validated

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Con: 30 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse heart tissue, transfected cells

Positive IHC detected in:
human oesophagus cancer tissue, human heart tissue, human oesophagus cancer tissue, human skeletal muscle tissue

Positive IF detected in:
NIH/3T3 cells

Recommended dilution:
WB : 1:200-1:1000
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
chromatin modifying protein 4B

Calculated molecular weight:
224aa,25 kDa

Observed molecular weight:
29-33 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CHMP4B

Synonyms
C20orf178, CHMP4B, chromatin modifying protein 4B, CTPP3, dJ553F4.4, hSnf7 2, hVps32 2, Shax1, SNF7, SNF7 2, Vps32 2
Background

CHMP4B (charged multivesicular body protein 4b) is a human homologue of yeast Snf7p (also named Vps32p) and a member of CHMP family which is implicated in multivesicular body (MVB) sorting. The CHMP proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies. Among seven CHMP family members, only CHMP4 has been found to interact with Alix, a multifunctional adaptor protein in various cellular functions. This antibody is highly specific to the CHMP4B and it doesn’t cross-react with other CHMPs as well as other CHMP4s (CHMP4A and CHMP4C).


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