CIN85 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 12132-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 28 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
Jurkat cells, fetal human brain tissue

Recommended dilution:
WB : 1:500-1:2000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
SH3-domain kinase binding protein 1

Calculated molecular weight:
665aa,73 kDa

Observed molecular weight:
85 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SH3KBP1

Synonyms
CD2 binding protein 3, CD2BP3, CIN85, GIG10, HSB 1, MIG18, SH3KBP1
Background

CIN85 is identified as a Cbl-interacting protein of 85 kDa and belongs to adaptor/scaffold proteins. It composed of three N-terminal SH3 domains followed by a proline-rich region and a C-terminal coiled-coil region. In association with c-Cbl (Casitas B-lineage lymphoma), an E3 ubiquitin ligase. As an adaptor protein, CIN85 is involved in Cbl-dependent EGFR internalization, intracellular receptor trafficking, sorting and degradation. Moreover, through the SH3 domains and the proline-rich region, CIN85 is implicated in many protein-protein interactions and it is found to play important roles in other processes such as apoptosis, rearrangement of actin cytoskeleton, cell adhesion, immunological synapse, cell migration and invasion.


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