Claudin 18 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 21126-1-AP

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Freight/Packing

Con: 37 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse kidney tissue

Positive IP detected in:
mouse stomach tissue

Positive IHC detected in:
human stomach tissue, human stomach cancer tissue, human pancreas cancer tissue, human ovary tumor tissue

Positive IF detected in:
MKN-45 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:400
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
claudin 18

Calculated molecular weight:
261aa,28 kDa

Observed molecular weight:
28-29 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CLDN18

Synonyms
claudin 18, CLDN18, SFTA5, SFTPJ
Background

Claudin 18 (CLDN18) belongs to the large claudin family of proteins, which are tetraspan transmembrane proteins of tight junctions (PMID: 11585919; 18036336). Claudins exhibit specific patterns of expression in different tissues (PMID: 15447685). CLDN18 is specifically expressed in the stomach and lung. CLDN18 has two alternatively spliced variants, CLDN18.1 and CLDN18.2. CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific (PMID: 11585919; 21832145). Altered CLDN18 expression has been reported in various human malignancies, including gastric cancer, lung adenocarcinoma, and pancreatic neoplasm (PMID: 17459057; 22076167; 21832145).


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