CPLX1 Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 10246-2-AP

  • Print page
  • Download PDF

-_-

Freight/Packing

Con: 20 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, mouse, rat

Positive WB detected in:
mouse brain tissue, rat brain tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
mouse brain tissue

Positive IF detected in:
SH-SY5Y cells

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
complexin 1

Calculated molecular weight:
15 kDa

Observed molecular weight:
15-20 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CPLX1

Synonyms
complexin 1, Complexin I, complexin1, CPLX1, CPX I, CPX1, Synaphin 2
Background

Complexin 1 (CPLX1) is a member of the complexin/synaphin gene family, which are cytosolic proteins that function in synaptic vesicle exocytosis. Complexins are enriched in neurons where they colocalize with syntaxin and SNAP-25. Complexins bind weakly to syntaxin alone and not at all to synaptobrevin and SNAP-25, but strongly to the SNAP receptor-core complex composed of these three molecules. Compexins also compete with alpha-SNAP for binding to the core complex but not with other interacting molecules, including synaptotagmin I, and regulate the sequential interactions of alpha-SNAP and synaptotagmins with the SNAP receptor during exocytosis. CLPX1 binds to the SNAP receptor complex and disrupts it, leading to the release of transmitters. Alterations of complexins may contribute to the molecular substrate for abnormalities of neural connectivity in severe mental disorders.


Back
to top