CRTC2,TORC2 Antibody 5 Publications

Rabbit Polyclonal| Catalog number: 12497-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 67 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HepG2 cells, HEK-293 cells, mouse liver tissue

Positive IHC detected in:
human gliomas tissue

Positive IF detected in:
Hela cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
CREB regulated transcription coactivator 2

Calculated molecular weight:
693aa,73 kDa

Observed molecular weight:
73 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CRTC2

Synonyms
CRTC2, RP11 422P24.6, TORC 2, TORC2, Transducer of CREB protein 2
Background

CRTC2, also named as TORC2, belongs to the TORC family. It is a transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. It acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. CRTC2 enhances the interaction of CREB1 with TAF4. Ir regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. CRTC2 regulates the expression of specific genes such as the steroidogenic gene, StAR. TORC2 was recently shown to be an important regulator of gluconeogenesis in the livers of mammals. It is one of the other key regulators of CRE-dependent MIE gene expression in NT2 cells. This regulation is linked to VIP-induced TORC2 dephosphorylation and translocation to the nucleus. (PMID: 19369332, 20504934 ) .


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