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KPNB1 mediates PER/CRY nuclear translocation and circadian clock function.
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Cryptochrome circadian clock 2 (CRY2) is a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. Loss of CRY2 stabilizes c-MYC and enhances cellular transformation. CRY2 can function as a co-factor for the SCF substrate adaptor FBXL3. (PMID: 27840026) CRY2 has two isoform with MW of 60, 67 kDa.