CSK Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 17720-1-AP

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Freight/Packing

Con: 48 μg/150 μl

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Species specificity:
human

Positive WB detected in:
HL-60 cells, Jurkat cells, K-562 cells, rat lung tissue

Positive IP detected in:
HL-60 cells

Positive IHC detected in:
human lung tissue,human skin tissue, human placenta tissue, human kidney tissue, human brain tissue, human ovary tissue, human testis tissue

Positive IF detected in:
SH-SY5Y cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
c-src tyrosine kinase

Calculated molecular weight:
450aa,50 kDa

Observed molecular weight:
50 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CSK

Synonyms
C Src kinase, c src tyrosine kinase, CSK, Protein tyrosine kinase CYL, Tyrosine protein kinase CSK
Background

CSK(Tyrosine-protein kinase CSK) is also named as C-Src kinase, protein-tyrosine kinase CYL and belongs to the protein kinase superfamily. Csk is a non-receptor tyrosine kinase with a molecular mass of 50 kDa. It contains the SH3 and SH2 domains in its N-terminus and a kinase domain in its C-terminus. It negatively regulates the kinase activity of SFKs and plays an important role in physiological functions via signaling pathways for cell proliferation, differentiation, adhesion, and migration(PMID:23548896). Csk may play a role in tumor suppression by inhibiting the oncogenic activity of SFKs. Indeed, overexpression of Csk can inhibit tumor growth of human colon cancer cells(PMID:23139636). This protein can be autophosphorylated(PMID:11181701).


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