CSNK1G1 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 16384-1-AP

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Con: 23 μg/150 μl

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Species specificity:
human, mouse, rat, monkey

Positive WB detected in:
Jurkat cells, COS-7 cells

Positive IP detected in:
Jurkat cells

Positive IHC detected in:
human liver tissue

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
casein kinase 1, gamma 1

Calculated molecular weight:
422aa,49 kDa

Observed molecular weight:
49 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CSNK1G1

Synonyms
casein kinase 1, gamma 1, CKI gamma 1, CSNK1G1
Background

The casein kinase 1 (CK1) is a family of Ser/Thr protein kinases that functions as regulator in signal transduction of eukaryotic cells. CSNK1G1(Casein kinase I isoform gamma-1) plays an important role in activating the ATR/Chk1 pathway by phosphorylating Claspin, which was identified as a Chk1-activating protein. Recently, it has been found that CSNK1G1 can phosphorylate NF-kB subunit p65 at Ser536, which promotes its ubiquitin-mediated degredation by E3 ligases COMMD1 and CUL2.(PMID:24442433). This protein has 2 isoforms produced by alternative splicing with the molecular weight of 49 kDa and 45 kDa.


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