CUGBP2 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 12921-1-AP

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Freight/Packing

Con: 76 μg/150 μl

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Species specificity:
human, mouse, rat, zebrafish

Positive WB detected in:
K-562 cells, K-562 cells, mouse thymus tissue

Positive IP detected in:
mouse skeletal muscle tissue

Positive IHC detected in:
human breast cancer tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
CUG triplet repeat, RNA binding protein 2

Calculated molecular weight:
56 kDa

Observed molecular weight:
50 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CUGBP2

Synonyms
Bruno like protein 3, BRUNOL3, CELF 2, CELF2, CUG BP2, CUGBP2, ETR 3, ETR3, hNAPOR, NAPOR, RNA binding protein BRUNOL 3
Background

The CELF (CUGBP and ETR-3 Like Factor)/Bruno-like protein family plays important roles in the regulation of alternative splicing and translation. CUGBP2 is a member of this family of proteins that possesses several alternatively spliced exons. CUGBP2 induces smooth muscle-specific exon inclusion via binding to uridine purine repeat elements (URE) in ACTN1. Although CUGBP2 is known as a splicing activator for the N-methyl-D-aspartate receptor 1 (NMDA R1) exon 21, CUGBP2 represses NMDA R1 exon 5 inclusion . In addition, CUGBP2 was reported to repress the inclusion of the Irexon 11


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