- Featured Product
- KD/KO Validated
CXCR4 Monoclonal Antibody for FC, WB, ELISA
Cat no : 60042-1-Ig
CD184, CXC R4, CXCR 4, CXCR4, CXCR4B, D2S201E, FB22, Fusin, HM89, HSY3RR, LAP3, LCR1, LESTR, SDF 1 receptor, WHIM
|Positive WB detected in||K-562 cells, Jurkat cells, U-937 cells|
|Positive FC detected in||Jurkat cells|
|Western Blot (WB)||WB : 1:500-1:2000|
|Sample-dependent, check data in validation data gallery|
60042-1-Ig targets CXCR4 in WB, IF, FC, ELISA applications and shows reactivity with human samples.
|Cited Reactivity||human, mouse|
|Host / Isotype||Mouse / IgM|
|Immunogen||CXCR4 fusion protein Ag1528|
|Full Name||chemokine (C-X-C motif) receptor 4|
|Calculated molecular weight||352aa,40 kDa|
|Observed molecular weight||60~70 kDa|
|GenBank accession number||BC020968|
|Gene ID (NCBI)||7852|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.1% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
C-X-C chemokine receptor type 4 (CXCR4) is a widely expressed G protein-coupled seven-transmembrane receptor. CXCL12/SDF-1 is the biological ligand for CXCR4. The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathways initiating signals related to chemotaxis, cell survival and/or proliferation, increase in intracellular calcium, and gene transcription (PMID: 20484021). CXCR4 also functions as a coreceptor for HIV-1 entry (PMID: 9427609). CXCR4 has a calculated molecular weight of 40 kDa. In addition to the predicted species of 45-47 kDa for glycosylated CXCR4 monomers, due to ubiquitination, dimeration, and different degrees of glycosylation, additional species can also exist and have been reported in some researches, including 67 kDa (PMID: 23917520), 55, 67, 87 kDa (PMID: 20028517), 80 kDa (PMID: 10506573), 47, 50, 62, and 98 kDa (PMID: 16204649).
J Cell Physiol
The overexpression of GRASP might inhibit cell proliferation and invasion in hepatocellular carcinoma.
Evid Based Complement Alternat Med
Combination of Ligusticum Chuanxiong and Radix Paeonia Promotes Angiogenesis in Ischemic Myocardium through Notch Signalling and Mobilization of Stem Cells.
Mol Med Rep
Taspine derivative TAS9 regulates cell growth and metastasis of human hepatocellular carcinoma.
Co-culture with TM4 cells enhances the proliferation and migration of rat adipose-derived mesenchymal stem cells with high stemness.
Scand J Gastroenterol
CXCR7 as a chemokine receptor for SDF-1 promotes gastric cancer progression via MAPK pathways.
Porphyromonas gingivalis-Induced MIF Regulates Intercellular Adhesion Molecule-1 Expression in EA.hy926 Cells and Monocyte-Endothelial Cell Adhesion Through the Receptors CD74 and CXCR4.