CYFIP1/2 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 16011-1-AP

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Freight/Packing

Con: 29 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
human brain tissue, mouse brain tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human gliomas tissue, human brain tissue

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cytoplasmic FMR1 interacting protein 2

Calculated molecular weight:
148 kDa

Observed molecular weight:
130 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CYFIP2

Synonyms
CYFIP2, KIAA1168, p53 inducible protein 121, PIR121
Background

CYFIP1/2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. CYFIP1 contains 1,253 amino acids and shares 88% sequence identity with CYFIP2. CYFIP1 and CYFIP2 are members of a highly conserved protein family and share approximately 99% sequence identity with their mouse orthologs. CYFIP1 has been shown to interact with the small GTPase RAC1, which is implicated in development and maintenance of neuronal structures. Consistent with FMRP and RAC1 localization in dendritic fine structures, CYFIP1/2 are present in synaptosomal extracts. This antibody can recognize both CYFIP1 and CYFIP2.


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