CYP11A1 Antibody 6 Publications

Rabbit Polyclonal| Catalog number: 13363-1-AP

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Con: 30 μg/150 μl

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Species specificity:
human, rat, mouse

Positive WB detected in:
human placenta tissue, HeLa cells, human placenta tissue

Positive IHC detected in:
human placenta tissue, human placenta tissue, human testis tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:100-1:400

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cytochrome P450, family 11, subfamily A, polypeptide 1

Calculated molecular weight:
521aa,60 kDa

Observed molecular weight:
49-52 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CYP11A1

Synonyms
Cholesterol desmolase, CYP11A, CYP11A1, CYPXIA1, Cytochrome P450 11A1, Cytochrome P450(scc), P450SCC
Background

CYP11A1 is also known as cytochrome P450C11A1, cytochrome P450scc and cytochrome P450, subfamily XIA. It is the first enzyme of all steroidogenic pathways, its elimination results in syndromes of steroid deficiency, including electrolyte imbalance, aberrant gene regulation, and suppression of male sex organ development(PMID: 12145347). Expression of CYP11A1 has been a useful tool for monitoring the differentiation state of cells from varius endocrine tissues. Identification of CYP11A1 expression by 13363-1-AP detected a ~45kd band in human placenta, with respect to the reported band at 49-52kd by Roby, et al and Durkee, et al. The murine 32-kDa isoform of Cyp11a1 is not produced by omission of the first ATG-containing exon (as is the case for human CYP11A1) but perhaps by alternative translational initiation(PMID:19342447).


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