CYP19A1 Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 16554-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 33 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
A2780 cells, A2780 cells, human testis tissue, mouse ovary tissue

Positive IHC detected in:
human gliomas tissue, human gliomas tissue, human kidney tissue, human lung tissue, human ovary tissue, human placenta tissue, human skeletal muscle tissue, human spleen tissue, human testis tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:100-1:400

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cytochrome P450, family 19, subfamily A, polypeptide 1

Calculated molecular weight:
20 kDa;25 kDa;58 kDa

Observed molecular weight:
49-55 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CYP19A1

Synonyms
ARO, ARO1, Aromatase, CPV1, CYAR, CYP19, CYP19A1, CYPXIX, Cytochrome P 450AROM, Cytochrome P450 19A1, Estrogen synthase, P 450AROM
Background

CYP19A1(Cytochrome P450 19A1) is also named as ARO1(aromatase), CYAR, CYP19, estrogen synthase and belongs to the cytochrome P450 family. It is a terminal enzyme which transforms irreversibly androgens into estrogens and it is present in the endoplasmic reticulum of numerous tissues(PMID:16406261). The gene encodes a protein with the molecular weight between 46 kDa and 69 kDa(PMID:8129748) and the protein can be glycosylated, but the level of glycosylation does not seem to be essential for CYP19A1 activity(PMID:12606587). Brain aromatase may be neuroprotective by increasing the local estrogen levels in injured neurons so that genetic variation in the brain aromatase gene may modify the risk for AD(PMID:16767510).


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