CYP24A1 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 21582-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 30 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, A549 cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:
human kidney tissue, human prostate cancer tissue

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cytochrome P450, family 24, subfamily A, polypeptide 1

Calculated molecular weight:
514aa,59 kDa

Observed molecular weight:
54-59 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CYP24A1

Synonyms
24 OHase, CP24, CYP24, CYP24A1, Cytochrome P450 24A1, Cytochrome P450 CC24, P450 CC24, Vitamin D(3) 24 hydroxylase
Background

CYP24A1(1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial) catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D3) and calcitriol (1-alpha,25-dihydroxyvitamin D3). Cholecalciferol is metabolised by the 25-hydroxylases (CYP2R1 and CYP27A1) in the liver, before 25-hydroxycholecalciferol (25(OH)D3) relocates to the circulation (PMID:20362668). The gene CYP24A1 has three isoforms, for the transit peptide "mitochondrial domain" removed, the MW of CYP24A1 will be 55-59 kDa, 47-51 kDa and 43 kDa. This antibody is specific to CYP24A1.


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