CYP27A1 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 14739-1-AP

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Con: 24 μg/150 μl

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Species specificity:
human, mouse, rat, rabbit

Positive WB detected in:
mouse liver tissue, NIH/3T3 cells

Positive IHC detected in:
human liver cancer tissue, human liver tissue, human liver cancer tissue

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:100-1:400

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cytochrome P450, family 27, subfamily A, polypeptide 1

Calculated molecular weight:
60 kDa

Observed molecular weight:
60-65 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CYP27A1

Synonyms
CP27, CTX, CYP27, CYP27A1, Cytochrome P 450C27/25, Cytochrome P450 27, Sterol 27 hydroxylase, Vitamin D(3) 25 hydroxylase
Background

Mitochondrial sterol 27-hydroxylase (CYP27A1) catalyzes oxidative cleavage of the sterol side chain in the bile acid biosynthetic pathway in the liver and 27-hydroxylation of cholesterol in most tissues(PMID:17088262). It belongs to the cytochrome P450 family. CYP27A1 catalyses an important sterol elimination pathway in the macrophage, and consequently may protect against atherosclerosis.


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