DCC-Specific Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 19123-1-AP

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Freight/Packing

Con: 64 μg/150 μl

Choose size:

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse brain tissue

Recommended dilution:
WB : 1:500-1:1000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
deleted in colorectal carcinoma

Calculated molecular weight:
1447aa,158 kDa

Observed molecular weight:
180 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DCC

Synonyms
Colorectal cancer suppressor, CRC18, CRCR1, DCC, IGDCC1, Netrin receptor DCC, Tumor suppressor protein DCC
Background

DCC, also named as IGDCC1, belongs to the immunoglobulin superfamily and DCC family. DCC is a receptor for netrin required for axon guidance. DCC mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. DCC gene is a tumor suppressor gene.


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