DDB2 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 10431-1-AP

  • Print page
  • Download PDF

-_-

Freight/Packing

Con: 26 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, A431 cells, HeLa cells

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
damage-specific DNA binding protein 2, 48kDa

Calculated molecular weight:
48 kDa

Observed molecular weight:
55-60 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DDB2

Synonyms
DDB p48 subunit, DDB2, DDBB, DNA damage binding protein 2, FLJ34321, UV DDB 2, UV DDB2
Background

DDB2, also named as DNA damage-binding protein 2 or UV-damaged DNA-binding protein 2, is a 427 amino acid protein, which contains seven WD repeats and belongs to the WD repeat DDB2/WDR76 family. DDB2 is ubiquitously expressed, with highest levels in corneal endothelium and lowest levels in brain. DDB2 localizes in the nucleus and is required for DNA repair. DDB2 regulates negatively the constitutive expression of the SOD2 gene in breast cancer cells and exerts, at least in part, a control of breast cacner cell growth. DDB2 can play a role as oncogene and may become a promising candidate as a predictive marker in breast cancer.


Back
to top