DHFR Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 15194-1-AP

Featured Product KD/KO validated

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Con: 20 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
K-562 cells, HeLa cells, Jurkat cells, Raji cells

Positive IP detected in:
Raji cells

Positive IHC detected in:
human liver cancer tissue, human breast cancer tissue, human liver cancer tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
dihydrofolate reductase

Calculated molecular weight:
21 kDa

Observed molecular weight:
21 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DHFR

Synonyms
DHFR, DHFRP1, dihydrofolate reductase
Background

DHFR(dihydrofolate reductase) catalyzes the subsequent NADPH-dependent reduction of the H2folate produced by TS to regenerate the tetrahydrofolate (H4folate) necessary for continued dTMP synthesis and transfer of 1-carbon units(PMID:3461439). It belongs to the dihydrofolate reductase family and can exsit as a homodimer(PMID:2248959). DHFR is widely expressed in fetal and adult human brain and whole blood,expression is higher in adult brain than fetal brain (PMID:21310276).


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