DOK4 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 10481-2-AP

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Freight/Packing

Con: 64 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
Transfected HEK-293 cells

Positive IHC detected in:
human prostate cancer tissue

Recommended dilution:
WB : 1:1000-1:4000
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
docking protein 4

Calculated molecular weight:
37 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DOK4

Synonyms
docking protein 4, DOK4, FLJ10488, Insulin receptor substrate 5, IRS 5, IRS5
Background

The insulin-receptor substrate family plays important roles in cellular growth, signaling and survival. IRS5/DOK4 is a new member of this family identified, which is known as docking protein 4, or downstream of tyrosine kinase-4. DOK4 might have roles in insulin and IGF-1 signaling as well. Expression of IRS5/DOK4 is regulated epigenetically via histone acetylating at its promoter. DOK4 is required at early stages in the myelination process, including the initial interaction with the axon, and is also involved in Schwann cell migration and proliferation, it also regulates GDNF-mediated neurite outgrowth during neuronal development through activation of the Rap1-ERK1/2 pathway. DOK4 may represent a novel negative regulator of T cells as other DOK family members like DOK1 and DOK2.


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