DTL Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 12896-1-AP

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Con: 20 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, L02 cells, MCF-7 cells

Positive IP detected in:
mouse testis tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:200-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IF : 1:50-1:500

Product Information


Purification method:
Antigen affinity purification


PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Full name:
denticleless homolog (Drosophila)

Calculated molecular weight:
730aa,79 kDa

Observed molecular weight:
79 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol

CDT2, CDW1, DCAF2, Denticleless protein homolog, DTL, L2DTL, RAMP

CDT2, also named as L2DTL or RAMP, is one of the substrate receptors of the Cullin Ring Ubiquitin Ligase 4 that targets for ubiquitin mediated degradation a number of substrates, such as CDT1, p21 and CHK1, involved in the regulation of cell cycle and survival. CDT2 overexpression was reported in breast (PMID: 18542055), gastric (PMID: 19672268) and ovarian carcinomas (PMID: 23995842) and rhabdomyosarcomas (PMID: 19235922) and associated with the aggressiveness of hepatocellular carcinomas (PMID: 17106265).

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