DTL Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 12896-1-AP

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Freight/Packing

Con: 20 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, L02 cells, MCF-7 cells

Positive IP detected in:
mouse testis tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:200-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
denticleless homolog (Drosophila)

Calculated molecular weight:
730aa,79 kDa

Observed molecular weight:
79 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DTL

Synonyms
CDT2, CDW1, DCAF2, Denticleless protein homolog, DTL, L2DTL, RAMP
Background

CDT2, also named as L2DTL or RAMP, is one of the substrate receptors of the Cullin Ring Ubiquitin Ligase 4 that targets for ubiquitin mediated degradation a number of substrates, such as CDT1, p21 and CHK1, involved in the regulation of cell cycle and survival. CDT2 overexpression was reported in breast (PMID: 18542055), gastric (PMID: 19672268) and ovarian carcinomas (PMID: 23995842) and rhabdomyosarcomas (PMID: 19235922) and associated with the aggressiveness of hepatocellular carcinomas (PMID: 17106265).


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