DUSP6 Antibody 4 Publications

Rabbit Polyclonal| Catalog number: 10433-1-AP

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Freight/Packing

Con: 50 μg/150 μl

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Tested Applications

Applications:
ELISA, IHC, WB
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Species specificity:
human, mouse, rat

Recommended dilution:

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
dual specificity phosphatase 6

Calculated molecular weight:
42.3 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
DUSP6

Synonyms
dual specificity phosphatase 6, DUSP6, MAP kinase phosphatase 3, MKP 3, MKP3, PYST1
Background

Dual specificity phosphatase 6 (DUSP6) is a member of the family of mitogen-activated protein kinase (MAPK) phosphatases, which dephosphorylate and inactivate MAPK (PMID: 9858808). The MAPK pathway is an important signal transduction system that serves cellular processes, such as proliferation, differentiation, migration, and apoptosis. DUSP6 resides at chromosome location 12q22-23, which is one of the candidate loci for susceptibility to bipolar disorder and which encodes a phosphatase selective for extracellular signal-regulated kinase (ERK) (PMID: 9205128). DUSP6 inactivates extracellular signal-regulated kinase (ERK), and can act in tumor suppressive pathways, whose expression is reduced in several different types of cancer. (PMID: 21680106).


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