Validation Data Gallery
|Sample-dependent, check data in validation data gallery|
10433-1-AP targets DUSP6 in WB, IHC,ELISA applications and shows reactivity with human samples.
|Cited Reactivity||human, mouse, rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||DUSP6 fusion protein Ag0705|
|Full Name||dual specificity phosphatase 6|
|Calculated molecular weight||42 aa, 3 kDa|
|GenBank accession number||BC003562|
|Gene ID (NCBI)||1848|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 0.02% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
Dual specificity phosphatase 6 (DUSP6) is a member of the family of mitogen-activated protein kinase (MAPK) phosphatases, which dephosphorylate and inactivate MAPK (PMID: 9858808). The MAPK pathway is an important signal transduction system that serves cellular processes, such as proliferation, differentiation, migration, and apoptosis. DUSP6 resides at chromosome location 12q22-23, which is one of the candidate loci for susceptibility to bipolar disorder and which encodes a phosphatase selective for extracellular signal-regulated kinase (ERK) (PMID: 9205128). DUSP6 inactivates extracellular signal-regulated kinase (ERK), and can act in tumor suppressive pathways, whose expression is reduced in several different types of cancer. (PMID: 21680106).
Biochim Biophys Acta
VRK3-mediated inactivation of ERK signaling in adult and embryonic rodent tissues.
Chin Med J (Engl)
Higher intratumor than peritumor expression of DUSP6/MKP-3 is associated with recurrence after curative resection of hepatocellular carcinoma.
Mol Cell Biochem
PP2A and DUSP6 are involved in sphingosylphosphorylcholine-induced hypopigmentation.
Br J Pharmacol
L-Hcy-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinemia.