DUSP6 Antibody

DUSP6 Polyclonal Antibody for ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human and More (2)

Applications

ELISA

Conjugate

Unconjugated

Cat no : 10433-1-AP

Synonyms

dual specificity phosphatase 6, DUSP6, MAP kinase phosphatase 3, MKP 3, MKP3, PYST1



Tested Applications

Recommended dilution

ApplicationDilution
Sample-dependent, check data in validation data gallery

Product Information

10433-1-AP targets DUSP6 in ELISA applications and shows reactivity with human samples.

Reactivity human
Cited Species human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen DUSP6 fusion protein Ag0705
Full Name dual specificity phosphatase 6
Calculated molecular weight 42.3 kDa
Observed molecular weight
GenBank accession number BC003562
Gene symbol DUSP6
Gene ID (NCBI) 1848
Conjugate Unconjugated
Form Liquid
Purification Method Antigen affinity purification
Storage Buffer PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20oC. Aliquoting is unnecessary for -20oC storage.

Background Information

Dual specificity phosphatase 6 (DUSP6) is a member of the family of mitogen-activated protein kinase (MAPK) phosphatases, which dephosphorylate and inactivate MAPK (PMID: 9858808). The MAPK pathway is an important signal transduction system that serves cellular processes, such as proliferation, differentiation, migration, and apoptosis. DUSP6 resides at chromosome location 12q22-23, which is one of the candidate loci for susceptibility to bipolar disorder and which encodes a phosphatase selective for extracellular signal-regulated kinase (ERK) (PMID: 9205128). DUSP6 inactivates extracellular signal-regulated kinase (ERK), and can act in tumor suppressive pathways, whose expression is reduced in several different types of cancer. (PMID: 21680106).

Publications

SpeciesApplicationTitle
ratWB

Biochim Biophys Acta

VRK3-mediated inactivation of ERK signaling in adult and embryonic rodent tissues.

Authors - Kang Tae-Hong TH
humanIHC

Chin Med J (Engl)

Higher intratumor than peritumor expression of DUSP6/MKP-3 is associated with recurrence after curative resection of hepatocellular carcinoma.

Authors - Bo Yang
mouseWB

Mol Cell Biochem

PP2A and DUSP6 are involved in sphingosylphosphorylcholine-induced hypopigmentation.

Authors - Jeong Hyo-Soon HS
humanWB

Br J Pharmacol

L-Hcy-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinemia.

Authors - Yi-Ping Leng