EGFR Antibody 1 Publications

Mouse Monoclonal| Catalog number: 66455-1-Ig |CloneNo.: 2A2H10

Featured Product KD/KO validated

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Freight/Packing

Con: 150 μg/150 μl

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Species specificity:
human

Positive WB detected in:
HepG2 cells

Positive IHC detected in:
human tonsillitis tissue, human colon cancer tissue, human breast cancer tissue, human skin tissue, human lung cancer tissue, human gliomas tissue, human cervical cancer tissue

Recommended dilution:
WB : 1:10000-1:20000
IHC : 1:400-1:1600

Product Information


Source:
Mouse

Purification method:
Protein G purification

Isotype:
IgG1

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)

Calculated molecular weight:
1210aa,134 kDa

Observed molecular weight:
145-165 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
EGFR

Synonyms
EGFR, ERBB, ERBB1, HER1, mENA, PIG61, Proto oncogene c ErbB 1
Background

EGFR, also named as ERBB1, is a cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. The gene resides on chromosome 7p12, encoding a 170 kDa membrane-associated glycoprotein. Recent studies have shown EGFR plays a critical role in cancer development and progression, including cell proliferation, apoptosis, angiogenesis, and metastatic spread. Mutations in this gene are associated with lung cancer.


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