PHD2 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 20368-1-AP

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Con: 59 μg/150 μl

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Species specificity:
human, mouse

Positive WB detected in:
HEK-293 cells, HEK-293 cells, mouse pancreas tissue

Positive IHC detected in:
human pancreas tissue, human heart tissue, human pancreas tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:100-1:400
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
egl nine homolog 1 (C. elegans)

Calculated molecular weight:
46 kDa

Observed molecular weight:
46 kDa,36 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
EGLN1

Synonyms
C1orf12, DKFZp761F179, ECYT3, Egl nine homolog 1, EGLN1, HIF PH2, HIF prolyl hydroxylase 2, HIFPH2, HPH 2, HPH2, PHD2, PNAS 137, SM 20, SM20, ZMYND6
Background

EGLN1, also named as PHD2, SM-20, HPH-2 and HIF-PH2, catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. It hydroxylates HIF-1 alpha at 'Pro-402' and 'Pro-564', and HIF-2 alpha. EGLN1 functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Defects in EGLN1 are the cause of erythrocytosis familial type 3 (ECYT3). The antibody is specific to EGLN1.


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