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ERBB3 Antibody 1 Publications

Rabbit Polyclonal| Catalog number: 10369-1-AP

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Con: 40 μg/150 μl

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Tested Applications

Applications:
WB, IHC, ELISA
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ERBB3 Antibody IHC human breast cancer tissue 10369-1-AP

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 10369-1-AP( ERBB3 Antibody) at dilution of 1:200 (under 10x lens).

ERBB3 Antibody IHC human breast cancer tissue 10369-1-AP

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 10369-1-AP( ERBB3 Antibody) at dilution of 1:200 (under 40x lens).

Species specificity:
human, mouse, rat
Positive IHC detected in:
human breast cancer tissue, human prostate cancer tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Recommended dilution:
IHC : 1:50-1:500

Protocols

Product-specific protocols

Standard Protocols

Product Information

Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Immunogen:
ERBB3 fusion protein Ag0215
Full name:
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Calculated molecular weight:
148 kDa
Observed molecular weight:
GenBank accession number:
BC002706
Gene ID (NCBI):
2065
Gene symbol
ERBB3
Synonyms
c erbB 3, c erbB3, ErbB 3, ERBB3, erbB3 S, HER3, LCCS2, MDA BF 1, p180 ErbB3, p45 sErbB3, p85 sErbB3

Background

V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (ErbB-3, HER3) is a member of the EGF receptor tyrosine kinase family including EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3), and ErbB-4 (HER4) that are frequently overexpressed in a variety of carcinomas. These family members form either homodimers or heterodimers upon ligand binding to mediate cell growth. ErbB-3 binds and is activated by neuregulins and NTAK. It forms a heterodimer with each of the other ErbB receptors. ErbB-3 is predominantly expressed in epithelial tissues and brain, and is overexpressed in a subset of human mammary tumors.


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