ERI1 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 14592-1-AP

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Freight/Packing

Con: 75 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
K-562 cells, HepG2 cells, HL-60 cells

Positive IHC detected in:
human testis tissue, human liver cancer tissue, human testis tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
exoribonuclease 1

Calculated molecular weight:
40 kDa

Observed molecular weight:
46kd

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ERI1

Synonyms
3 5 exonuclease ERI1, 3 5 exoribonuclease 1, 3EXO, 3'HEXO, Eri 1 homolog, ERI1, exoribonuclease 1, HEXO, Histone mRNA 3 exonuclease 1, Protein 3hExo, THEX1
Background

ERI1, also named as HEXO, 3'HEXO and THEX1, contains one exonuclease domain and one SAP domain. The SAP domain is necessary for binding to the stem-loop structure of histone mRNAs and to form the ternary complex with SLBP, but not for 3'-end histone mRNA exonuclease activity. It is a RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. It is able to bind other mRNAs. ERI1 is required for 5.8S rRNA 3'-end processing. It also binds to 5.8s ribosomal RNA. ERI1 binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.


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