ER Antibody 12 Publications

Rabbit Polyclonal| Catalog number: 21244-1-AP

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Freight/Packing

Con: 75 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
MCF-7 cells, mouse testis tissue, HeLa cells, rat testis tissue, NIH/3T3 cells

Positive IHC detected in:
human breast cancer tissue, human cervical cancer tissue, human ovary tumor tissue

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:200-1:800

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
estrogen receptor 1

Calculated molecular weight:
595aa,66 kDa

Observed molecular weight:
65-70 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
ESR1

Synonyms
DKFZp686N23123, ER, ER alpha, Era, ESR, ESR1, ESRA, Estradiol receptor, Estrogen receptor, estrogen receptor 1, NR3A1
Background

The estrogen receptor (ESR, ER) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. ESR1, also known as ESR or NR3A1, belongs to the nuclear hormone receptor family and NR3 subfamily. It is a nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. ESR1 can activate the transcriptional activity of TFF1.[PMID: 11731608,10970861]


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