EXOSC8 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 11979-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 36 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
HeLa cells, HEK-293 cells, human brain tissue

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:
human testis tissue, human colon tissue, human pancreas cancer tissue, human testis tissue

Positive IF detected in:
4T1 cells

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:20-1:200
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
exosome component 8

Calculated molecular weight:
276aa,30 kDa

Observed molecular weight:
30-35 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
EXOSC8

Synonyms
bA421P11.3, CIP3, EAP2, EXOSC8, exosome component 8, OIP 2, OIP2, Opa interacting protein 2, p9, RP11 421P11.3, RRP43, Rrp43p
Background

EXOSC8 (exosome component 8), also known as p9 or CIP3, is a component of the exosome multi-enzyme ribonuclease complex, that degrades or processes messenger RNA. It belongs to the RNase PH family and localizes to the nucleolus. EXOSC8 is one of the six RNase-PH domain subunits of the exosome. EXOSC8 is part of the central hexamer channel of the exosome. EXOSC8 mutations could alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia.


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