FAF2 Antibody 5 Publications

Rabbit Polyclonal| Catalog number: 16251-1-AP

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Freight/Packing

Con: 59 μg/150 μl

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Species specificity:
human, mouse, rat, cow

Positive WB detected in:
mouse brain tissue, HeLa cells, HepG2 cells, human brain tissue, human heart tissue, human pancreas tissue, mouse brain tissue, mouse heart tissue, mouse lung tissue, mouse pancreas tissue, mouse testis tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:
human testis tissue

Positive IF detected in:
PC-3 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
Fas associated factor family member 2

Calculated molecular weight:
445aa,53 kDa

Observed molecular weight:
53 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
FAF2

Synonyms
ETEA, FAF2, FAS associated factor 2, KIAA0887, Protein ETEA, UBXD8, UBXN3B
Background

Protein ETEA (FAF2, or UBXD8) is a homolog to Fas-associated factor 1 (FAF1), which is involved in Fas-mediated apoptosis. ETEA protein directly interacts with and negatively regulates neurofibromin. ETEA contains both UBA and UBX domains and overexpression of ETEA downregulates neurofibromin in human cells. It may play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. ETEA is highly expressed in peripheral blood of patients with atopic dermatitis (AD) compared to normal individuals, and may regulate the resistance to apoptosis that is observed in T cells and eosinophils of AD patients.


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