Fibulin 5 Antibody 2 Publications

Mouse Monoclonal| Catalog number: 60081-1-Ig |CloneNo.: 2A5C8

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Freight/Packing

Con: 180 μg/150 μl

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Species specificity:
human, mouse, rat, pig

Positive WB detected in:
MCF-7 cells, human heart tissue, human placenta tissue, pig heart tissue, rat heart tissue

Positive IF detected in:
A549 cells

Recommended dilution:
WB : 1:1000-1:6000
IF : 1:50-1:100

Product Information


Source:
Mouse

Purification method:
Caprylic acid/ammonium sulfate precipitation

Isotype:
IgG1

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
fibulin 5

Calculated molecular weight:
448aa,50 kDa

Observed molecular weight:
65 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
FBLN5

Synonyms
ARMD3, DANCE, EVEC, FBLN5, FIBL 5, fibulin 5, FLJ90059, UP50, Urine p50 protein
Background

Fibulin-5, also known as EVEC and DANCE, is a extracellular matrix glycoprotein, secreted by various cell types such as vascular smooth muscle cells, fibroblasts and endothelial cells. Structurally, Fibulin-5 contains an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. FBLN5 mutations have been described in patients with age-related macular degeneration, as well as being involved in Charcot-Marie-Tooth neuropathies.


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