FBXW7 Antibody 3 Publications

Rabbit Polyclonal| Catalog number: 55290-1-AP

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Freight/Packing

Con: 29 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
human brain tissue, HEK-293 cells, human brain tissue, rat brain tissue

Positive IHC detected in:
human skin cancer tissue, human skeletal muscle tissue, human skin cancer tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:100-1:400
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
F-box and WD repeat domain containing 7

Calculated molecular weight:
80 kDa

Observed molecular weight:
60-65 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
FBXW7

Synonyms
AGO, Archipelago homolog, CDC4, DKFZp686F23254, F box protein FBX30, FBW6, FBW7, FBX30, FBXO30, FBXW6, FBXW7, FLJ16457, hAgo, hCdc4, SEL 10, SEL10
Background

FBXW7, also named as FBW7, FBX30, SEL10 and hAgo, is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It probably recognizes and binds to phosphorylated target proteins. FBXW7 is involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. This antibody is specific to FBXW7. It can recognize all the isoform of FBXW7.


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