FOLR1 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 23355-1-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 79 μg/150 μl

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Species specificity:
human

Positive WB detected in:
HeLa cells

Positive IHC detected in:
human breast cancer tissue

Positive IF detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:500
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
folate receptor 1 (adult)

Calculated molecular weight:
257aa,30 kDa

Observed molecular weight:
38 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
FOLR1

Synonyms
Adult folate binding protein, FBP, Folate receptor 1, folate receptor 1 (adult), Folate receptor alpha, Folate receptor, adult, FOLR, FOLR1, FR alpha, KB cells FBP, MOv18
Background

Folate receptor 1 (FOLR1), also known as folate receptor alpha or adult folate-binding protein (FBP), is a 38-kDa glycoprotein belonging to the folate receptor family (PMID:15094207; 23528302). The receptor binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. FOLR1 is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. FOLR1 expression is often limited to the apical surfaces of epithelium in the lung, kidney and choroid plexus but is differentially overexpressed in a variety of solid tumors such as ovarian cancer, non-small cell lung cancer, breast cancer, kidney cancer and high-grade osteosarcoma (PMID: 23528302; 23357463).


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