FOXA2 Antibody 0 Publications

Rabbit Polyclonal| Catalog number: 22474-1-AP

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Freight/Packing

Con: 30 μg/150 μl

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Species specificity:
human

Positive WB detected in:
A549 cells, A549 cells, HepG2 cells, PC-13 cells

Positive IP detected in:
HepG2 cells

Positive IHC detected in:
human pancreas tissue, human liver cancer tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:200-1:1000 for WB
IHC : 1:20-1:200
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen Affinity purified

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
forkhead box A2

Calculated molecular weight:
457aa,48 kDa

Observed molecular weight:
55-65 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
FOXA2

Synonyms
forkhead box A2, Forkhead box protein A2, FOXA2, HNF 3 beta, HNF 3B, HNF3B, TCF 3B, TCF3B, Transcription factor 3B
Background

FOXA2 also named as HNF 3 beta or TCF3B is a 457 amino acid protein, which contains one fork-head DNA-binding domains. FOXA2 can Shuttle between the nucleus and cytoplasm in a CRM1-dependent manner. Phosphorylation on FOXA2 Thr-156 abolishes binding to target promoters and subsequent transcription activation upon insulin stimulation. FOXA2 as a transcription factor involves in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. The molecular weight of FOXA2 is 48kDa, but the phosphorylated FOXA2 may be a 55-65kDa protein.


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