FOXC2 Antibody 2 Publications

Rabbit Polyclonal| Catalog number: 23066-1-AP

  • Print page
  • Download PDF

Be the first to review this product


-_-

Freight/Packing

Con: 44 μg/150 μl

Choose size:

Please visit your regions distributor:


Species specificity:
human, rat, mouse

Positive WB detected in:
A375 cells, A375 cells, A431 cells, rat spleen tissue

Positive IF detected in:
A375 cells

Recommended dilution:
WB : 1:500-1:2000
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen Affinity purified

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
forkhead box C2 (MFH-1, mesenchyme forkhead 1)

Calculated molecular weight:
501aa,54 kDa

Observed molecular weight:
56 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
FOXC2

Synonyms
FKHL14, Forkhead box protein C2, FOXC2, LD, Mesenchyme fork head protein 1, MFH 1, MFH 1 protein, MFH1, Transcription factor FKH 14
Background

Transcriptional activator. Might be involved in the formation of special mesenchymal tissues.Defects in FOXC2 are the cause of lymphedema hereditary type 2 (LMPH2) [MIM:153200]; also known as Meige lymphedema. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections, and physical impairment. Defects in FOXC2 are a cause of lymphedema-yellow nails (LYYN) [MIM:153300]. LYYN is characterized by yellow, dystrophic, thick and slowly growing nails, associated with lymphedema and respiratory involvement. Lymphedema occurs more often in the lower limbs. It can appear at birth or later in life. Onset generally follows the onset of ungual abnormalities. Defects in FOXC2 are a cause of lymphedema-distichiasis (LYD) [MIM:153400]. LYD is characterized by primary limb lymphedema usually starting at puberty (but in some cases later or at birth) and associated with distichiasis (double rows of eyelashes, with extra eyelashes growing from the Meibomian gland orifices).This antibody specifically recognizes the 56 kDa FOXC2 protein.


Back
to top